Chimeric Epitope Vaccine from Multistage Antigens for Lymphatic Filariasis
نویسندگان
چکیده
منابع مشابه
Endpoints for Lymphatic Filariasis Programs
In 2000, annual mass administration of diethlycarbamazine and albendazole began in Leogane Commune, Haiti, to interrupt transmission of lymphatic filariasis (LF). After 5 years of treatment, microfilaremia, antigenemia, and mosquito infection rates were significantly reduced, but LF transmission was not interrupted. These finding have implications for other LF elimination programs.
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Wuchereria brancofti, Brugia malayi, Brugia timori are the main parasites which causes lymphatic filariasis. Lymphatic filariasis is a neglected topical disease with more than 1.3 billoin people worldwide. These are spread from by blood-feeding black flies and mosquitoes. These worms occupy the lymphatic system, including the lymph nodes; in chronic cases, these worms lead to the disease elepha...
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Lymphatic filariasis is one of the neglected tropical diseases. It is estimated that 120 million people are currently infected in 73 countries where filariasis is endemic. Lymphatic filariasis is a leading cause of chronic disability worldwide, including of 15 million people who have lymphoedema (elephantiasis) and 25 million men who have hydrocoele.
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Rational strategies for obtaining malaria vaccine candidates should include not only a proper selection of target antigens for antibody stimulation, but also a versatile molecular design based on ordering the right pieces from the complex pathogen molecular puzzle towards more active and functional immunogens. Classical Plasmodium falciparum antigens regarded as vaccine candidates have been sel...
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BACKGROUND Lymphatic filariasis (LF) is a parasitic disease caused mainly by the Wuchereria bancrofti worm and that affects up to 120 million people worldwide. LF is the second cause of chronic global deformity, responsible for 15 million people with lymphedema (elephantiasis) and 25 million men with scrotal hydrocele. Its diagnosis is still associated with numerous difficulties, such as the sa...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2015
ISSN: 0300-9475
DOI: 10.1111/sji.12340